In real life, the predictable problems with curing Alzheimer's disease through gene therapy would most likely not be rejection of the new DNA from brain cells. The subject is resistant to therapy then. However, since the DNA carrier is a virus, with each therapy, there is a chance that the body's immune system will respond and create immunity against the carrier virus so much that the virus is, at one point, cleared from the body before having had effect. How this occurs is not explained in detail, but one of the drawbacks encountered in reality is the fact that delivery of genetic information to the cells is not stable the newly added DNA is foreign, and therefore not copied into new cells, and therefore rejected repeated treatment will be necessary. Practically, there are many problems and limitations associated with gene therapy the movie suggests that the patient's immune system starts to reject the therapy. That virus would carry a piece of suitable genetic information (DNA) and release it inside the human cells, which would then lead to those cells producing the necessary protein(s), thereby compensating for the defects caused by the disease. A virus must be engineered that exhibits the normal capacity to invade human cells, yet none of its normally destructive properties. Viral gene therapy could prove to be useful in diseases or syndromes that are caused by a lack of certain proteins. Several clinical trials have attempted to apply gene therapy, but the results have not yet yielded the therapeutic success as seen in the movie. Although the movie understandably simplifies this mechanism and its characteristics, it is an approach that has a sound theoretical basis and some evidence in practice. Also, Caesar's first word being "no" was part of the story that was told by Caesar's father Cornelius about how one Ape stood up and said "no" to its masters which lead to revolution.Īs the film briefly explains, the intention to treat Alzheimer's disease in the movie is through viral gene therapy. After witnessing mankind's capacity for cruelty towards apes, Caesar starts teaching other apes how to work together and eventually starts a revolt. The main ape is named Caesar, he's also the only advanced/intelligent ape. The remake elements of this film are mostly borrowed from elements of Conquest of the Planet of the Apes. It isn't exactly like the original series, as it doesn't include everything from all of the films, but it sticks to the core concept of an ape uprising with added depth to ground it in a plausible reality. In order to be truer to the mythology, there are some refinements. Also, special effects technology didn't allow for realistic apes. Back when the original series came out, people didn't know as much as they do today about apes, and the audience was led to believe that the apes simply evolved into a talking, intelligent species. The reboot part follows the mythology of the original series, but updates some things in order to improve on some of the weaknesses and inaccuracies of the original films. This movie sets up the chain of events that led to events that were originally depicted in the first movie, such as the ape revolt and the Icarus space mission (which carries the astronauts who will one day return to an ape-dominated Earth in the future). The prequel element is basically the fact that this movie takes place on Earth at present day, so chronologically before Planet of the Apes, which took place in the distant future. The basis thing to understand is that it starts fresh with a new continuity that is separate of the original Planet of the Apes franchise. It has elements of a prequel (mostly to the original Planet of the Apes film), as well as elements of a remake of the story set by Conquest of the Planet of the Apes. Rise of the Planet of the Apes is a reboot of the original Planet of the Apes series.
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